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OALib Journal期刊

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Screening of C‐kit gene Mutation in Acute Myeloid Leukaemia in Northern India
Hussain SR,Raza ST,Babu SG,Singh P
Iranian Journal of Cancer Prevention , 2012,
Abstract: Background: Acute Myeloid Leukaemia (AML) is a cancer of blood-forming cellsin bone marrow. C-kit gene is a Receptor Tyrosine Kinase class III (RTK) that isexpressed by early hematopoietic progenitor cells and plays an important role inhematopoietic stem cell proliferation, differentiation and survival. It is known thatc-kit is a proto-oncogene and the activating c-kit mutations are likely to contributein the development of leukaemia in humans. Exon 11 of c-Kit gene is the frequentsite for mutations in different kinds of tumours.Methods: In order to determine the frequency and prevalence of exon 11mutations in 51 AML cases, we have done polymerase chain reaction-single-strandconformational polymorphism followed by direct DNA sequencing.Results: The c-kit mutations in exon 11 were detected in 15.68% (8/51) in AMLcases. We have detected totally ten missense mutations in eight AML cases thoseinclude Lys550Asn, Tyr568Ser, Ile571Leu, Tyr578Pro, Trp582Ser andArg588Met and novel missense mutations at codons Ile563Lys and Val569Leu.Mutations at codons Ile571Leu and Trp582Ser was found in two independentcases.Conclusion: The presence of c-kit mutations in our study adds to investigativespectrum of AML cases. Since the c-kit mutations are seen in other malignancies,mutations in exon 11 of the c-kit gene might be involve in pathogenesis andrepresent useful predictive genetic marker in AML. Further studies in larger groupof cases possibly will be required to determine the prognostic implications and toinvestigate how these mutations are co-related to the progression andpathogenesis of AML.
Kinematic and Dynamic Analysis of the 2-DOF Spherical Wrist of Orthoglide 5-axis
Raza Ur-Rehman,Stéphane Caro,Damien Chablat,Philippe Wenger
Physics , 2009,
Abstract: This paper deals with the kinematics and dynamics of a two degree of freedom spherical manipulator, the wrist of Orthoglide 5-axis. The latter is a parallel kinematics machine composed of two manipulators: i) the Orthoglide 3-axis; a three-dof translational parallel manipulator that belongs to the family of Delta robots, and ii) the Agile eye; a two-dof parallel spherical wrist. The geometric and inertial parameters used in the model are determined by means of a CAD software. The performance of the spherical wrist is emphasized by means of several test trajectories. The effects of machining and/or cutting forces and the length of the cutting tool on the dynamic performance of the wrist are also analyzed. Finally, a preliminary selection of the motors is proposed from the velocities and torques required by the actuators to carry out the test trajectories.
Kinematic and Dynamic Analyses of the Orthoglide 5-axis
Raza Ur-Rehman,Stéphane Caro,Damien Chablat,Philippe Wenger
Computer Science , 2008,
Abstract: This paper deals with the kinematic and dynamic analyses of the Orthoglide 5-axis, a five-degree-of-freedom manipulator. It is derived from two manipulators: i) the Orthoglide 3-axis; a three dof translational manipulator and ii) the Agile eye; a parallel spherical wrist. First, the kinematic and dynamic models of the Orthoglide 5-axis are developed. The geometric and inertial parameters of the manipulator are determined by means of a CAD software. Then, the required motors performances are evaluated for some test trajectories. Finally, the motors are selected in the catalogue from the previous results.
Comparison of Planar Parallel Manipulator Architectures based on a Multi-objective Design Optimization Approach
Damien Chablat,Stéphane Caro,Raza Ur-Rehman,Philippe Wenger
Computer Science , 2010,
Abstract: This paper deals with the comparison of planar parallel manipulator architectures based on a multi-objective design optimization approach. The manipulator architectures are compared with regard to their mass in motion and their regular workspace size, i.e., the objective functions. The optimization problem is subject to constraints on the manipulator dexterity and stiffness. For a given external wrench, the displacements of the moving platform have to be smaller than given values throughout the obtained maximum regular dexterous workspace. The contributions of the paper are highlighted with the study of 3-RPR, 3-RPR and 3-RPR planar parallel manipulator architectures, which are compared by means of their Pareto frontiers obtained with a genetic algorithm.
Path placement optimization of manipulators based on energy consumption: application to the orthoglide 3-axis
Raza Ur-Rehman,Stéphane Caro,Damien Chablat,Philippe Wenger
Computer Science , 2009,
Abstract: This paper deals with the optimal path placement for a manipulator based on energy consumption. It proposes a methodology to determine the optimal location of a given test path within the workspace of a manipulator with minimal electric energy used by the actuators while taking into account the geometric, kinematic and dynamic constraints. The proposed methodology is applied to the Orthoglide~3-axis, a three-degree-of-freedom translational parallel kinematic machine (PKM), as an illustrative example.
Sobolev Gradient Approach for Huxley and Fisher Models for Gene Propagation  [PDF]
Nauman Raza, Sultan Sial
Applied Mathematics (AM) , 2013, DOI: 10.4236/am.2013.48163
Abstract:

The application of Sobolev gradient methods for finding critical points of the Huxley and Fisher models is demonstrated. A comparison is given between the Euclidean, weighted and unweighted Sobolev gradients. Results are given for the one dimensional Huxley and Fisher models.

Nonlinear Computational Model of Biological Cell Proliferation and Nutrient Delivery in a Bioreactor  [PDF]
Muhammad Shakeel, Sahar Raza
Applied Mathematics (AM) , 2014, DOI: 10.4236/am.2014.515222
Abstract:

Tissue engineering is a preeminent field which aims to regenerate or repair the functions of devastated or damaged organs or tissues due to some accident, disease or age related degeneration. This field provides immense help in saving lives of thousands of patients. Tissues or organs are engineered within the patient’s body or in a laboratory, which is later implanted in the patient’s body. The important challenges for tissue engineers are: appropriate nutrients supply and optimum cell density with uniform distribution of cells in a final construct. Mathematical modeling is the best tool in order to understand the mechanism of cell proliferation and nutrient supply in a bioreactor. Mathematical models not only help to analyze potentially useful results but also enlighten the way of further research. In this work, a simple mathematical model of diffusive nutrient transport and non-linear cell proliferation in a bioreactor is developed. A cell seeded porous scaffold is kept in a bioreactor with a fixed nutrient supply. We model the consumption and transport of nutrients by reaction-diffusion equation and cell proliferation by Fisher Kolmogorove equation. Nutrient delivery to the cell seeded scaffold is purely due to diffusion. The model is solved numerically by commercial finite element solver COMSOL. The results show that all types of constructs, if nutrient supply depends on diffusion, will produce cell proliferated regions near nutrient supply. The results are presented for uniform and non-uniform initial cell seeding strategies. It is also observed that cell proliferation is insensitive to the initial seeding strategy.

Enhancing the Performance of Current Online Education System—A Study of Cloud Computing and Virtualization  [PDF]
Basheer Riskhan, Raza Muhammed
Journal of Computer and Communications (JCC) , 2015, DOI: 10.4236/jcc.2015.310006
Abstract: Online Education (OE) system is an effective and efficient way to perform the education in all sectors of government and non-government educational organization. Low performance and minimum speed are major overhead in the current ongoing OE system due to the increase of users and some system issues. Base on the previous study and recent practical issues, a model is proposed to Enhancing the Performance of Online Education System (EPOES) to examine the bare metal virtualization, isolation and virtual machine templates. Bare metal virtualization has led the native execution, isolation isolated the running application and Virtual Machine Template has help to increase efficiency, avoiding the repetitive installation and operate the server in less time. The proposed model boosts the performance of the current OE system, and examines the benefits of the adaptation of cloud computing and virtualization which can be used to overcome the existing challenges and barriers of the current OE System.
Esext3 for Reducing the Effect of Harboring Bug in File System  [PDF]
Raza Muhammad, Basheer Riskhan
Journal of Software Engineering and Applications (JSEA) , 2017, DOI: 10.4236/jsea.2017.104021
Abstract: One of the most critical threats to the reliability and robustness for file system is harboring bug (silent data corruption). In this research we focus on checksum mismatch since it occurs not only in the user data but also in file system. Our proposed solution has the ability to check this bug in file system of Linux. In our proposed solution there is no need to invoke or revoke checker utility, it comes as the integrated part of file system and has the ability to check upcoming updates before harboring bug make unrecoverable changes that leads significant data loses. Demonstration testing shows satisfactory results in file server and web server environments in terms of less memory consumption and avoidable delay in system’s updating.
Non-equilibrium Green's function based single-band tight-binding model for Fe-MgO-Fe magnetic tunnel junction devices
Tehseen Raza,Hassan Raza
Physics , 2008,
Abstract: Motivated by observation of very high tunnel magnetoresistance (TMR) in Fe-MgO-Fe magnetic tunnel junction devices, we propose a theoretical model for these devices based on a single-band tight-binding approximation. An effort is made to capture the band dispersions over the two dimensional transverse Brillouin zone. In the transport direction, spin dependent Hamiltonian is prescribed for Delta_1 and Delta_5 bands. Non-equilibrium Green's function formalism is then used to calculate transport. Features like voltage dependence of TMR are captured quantitatively within this simple model and the trends match well with the ones predicted by ab-initio methods and experiments.
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